Recombinant Mouse fibroblast growth factor receptor 3 Protein, His&StrepII tagged

• Cat.No.: Fgfr3-021M
• Product Overview: Recombinant mouse FGFR3 protein (Q61851) (Glu 21-Gly 369) with a Strep II tag at the N-terminus and a His tag at the C-terminus was expressed in HEK293.

Specification

• Species: Mouse
• Source: HEK293
• Tag: His&Strep II
• Protein Length: 21-369aa
• Description: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers.
• Tag: N-StrepII and C-His
• Molecular Mass: 40.6 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus (house mouse) ]
• Official Symbol: Fgfr3
• Synonyms: FGFR3; fibroblast growth factor receptor 3; heparin-binding growth factor receptor; FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
• Gene ID: 14184
• mRNA Refseq: NM_001163215
• Protein Refseq: NP_001156687
• UniProt ID: Q61851