Recombinant Human Fibroblast Growth Factor Receptor 3
Cat.No. : | FGFR3-5003H |
Product Overview : | Recombinant human FGFR3 was expressed in Insect cells and purified by using conventional chromatography techniques. |
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Species : | Human |
Source : | Human |
Tag : | Non |
Description : | Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. |
Form : | Supplied as a lyophilized powder with no preservative. Reconstitute in sterile water to a concentration > 0.05mg/ml. |
Purity : | >90% pure by SDS PAGE |
Molecular Mass : | 170 kDa |
Applications : | Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions |
Endotoxin Levels : | <0.1 ng per g of sFGF-R3a |
Storage : | Store at -70 deg C until reconstitution. Following reconstitution product should be aliquoted and frozen at -20 deg C. Avoid repeated freeze/thaw cycles. |
Gene Name | FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ] |
Official Symbol | FGFR3 |
Synonyms | FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; OTTHUMP00000149958; OTTHUMP00000149959; tyrosine kinase JTK4; hydroxyaryl-protein kinase; achondroplasia, thanatophoric dwarfism; EC 2.7.10.1; FGFR-3; CD333 antigen |
Gene ID | 2261 |
mRNA Refseq | NM_000142 |
Protein Refseq | NP_000133 |
MIM | 134934 |
UniProt ID | P22607 |
Chromosome Location | 4p16.3 |
Pathway | Bladder cancer; Endocytosis; MAPK signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR |
Function | ATP binding; fibroblast growth factor receptor activity; identical protein binding; nucleotide binding; receptor activity; transferase activity |
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Not For Human Consumption!
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