Recombinant Human Fibroblast Growth Factor Receptor 3

Cat.No. : FGFR3-5003H
Product Overview : Recombinant human FGFR3 was expressed in Insect cells and purified by using conventional chromatography techniques.
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Species : Human
Source : Human
Tag : Non
Description : Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known.
Form : Supplied as a lyophilized powder with no preservative. Reconstitute in sterile water to a concentration > 0.05mg/ml.
Purity : >90% pure by SDS PAGE
Molecular Mass : 170 kDa
Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels : <0.1 ng per g of sFGF-R3a
Storage : Store at -70 deg C until reconstitution. Following reconstitution product should be aliquoted and frozen at -20 deg C. Avoid repeated freeze/thaw cycles.
Gene Name FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
Official Symbol FGFR3
Synonyms FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; OTTHUMP00000149958; OTTHUMP00000149959; tyrosine kinase JTK4; hydroxyaryl-protein kinase; achondroplasia, thanatophoric dwarfism; EC 2.7.10.1; FGFR-3; CD333 antigen
Gene ID 2261
mRNA Refseq NM_000142
Protein Refseq NP_000133
MIM 134934
UniProt ID P22607
Chromosome Location 4p16.3
Pathway Bladder cancer; Endocytosis; MAPK signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR
Function ATP binding; fibroblast growth factor receptor activity; identical protein binding; nucleotide binding; receptor activity; transferase activity

Not For Human Consumption!

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