Recombinant Human FGFR3 Protein, His-tagged

Cat.No. : FGFR3-151H
Product Overview : Recombinant Human fibroblast growth factor receptor 3(FGFR3), transcript variant 2(NM_022965), with a His tag, was expressed in human cells.
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Species : Human
Source : Human Cells
Tag : His
Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Form : Purified protein formulated in a sterile solution of TBS buffer, pH7.168, without any preservatives.
Molecular Mass : 34 kDa
Endotoxin : Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Purity : >90% by SDS-PAGE gel and Coomassie Blue staining
Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.
Gene Name FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
Official Symbol FGFR3
Synonyms FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX;
Gene ID 2261
mRNA Refseq NM_000142
Protein Refseq NP_000133
MIM 134934
UniProt ID P22607

Not For Human Consumption!

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