Recombinant Human Fibroblast Growth Factor Receptor 3, His-tagged

• Cat.No.: FGFR3-5419H
• Product Overview: Recombinant humanFGFR3 cytoplasmic domain (amino acids 399-806), His-tagged. No specialmeasures were taken to activate this kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 399-806 a.a.
• Description: FGFs comprise a family of atleast eighteen structurally realted proteins that are involved in a multitudeof physiological and pathological cellular processes, including cell growth,differentation, angiogenesis, wound healing and tumorgenesis. The biologicalactivities of the FGFs are mediated by a family if type I transmembranetyrosine kinases which undergo dimerization and autophosphorylation afterligand binding.
• MolecularWeight: 49.8 kDa
• Form: Liquid in 50 mMTris, pH 7.5 + 100 mM NaCl + 0.2 mM EDTA + 0.05% Triton X-100 + 5 mM DTT +50% glycerol.
• Purity: ≥ 90% as determinedby SDS-PAGE analysis
• Specific Activity: 550 nmoleof phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 2μg/ml.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FGFR3

Gene Information

• Gene Name: FGFR3 fibroblast growth factorreceptor 3 [ Homo sapiens ]
• Synonyms: FGFR3; fibroblast growth factorreceptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; OTTHUMP00000149958;OTTHUMP00000149959; tyrosine kinase JTK4; hydroxyaryl-protein kinase;achondroplasia, thanatophoric dwarfism; EC 2.7.10.1; FGFR-3; CD333 antigen
• Gene ID: 2261
• mRNA Refseq: NM_000142
• Protein Refseq: NP_000133
• MIM: 134934
• UniProt ID: P22607
• Chromosome Location: 4p16.3
• Pathway: Bladder cancer; Endocytosis;MAPK signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton;Signaling by FGFR
• Function: ATP binding; fibroblast growthfactor receptor activity; identical protein binding; nucleotide binding;receptor activity; transferase activity