Recombinant Human FGFR3 Protein, Fc-His-tagged

• Cat.No.: FGFR3-001H
• Product Overview: Recombinant Human FGFR3 Protein (1-372 aa (extracellular domain)) with Fc and 6xHis tag was expressed in HEK293E cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc&His
• Protein Length: 1-372
• Description: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
• Form: Frozen / Solution
• Molecular Mass: 66.4 kDa plus glycosylation.
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB) and immunoblotted with monoclonal antibody against human FGFR3 (WB).
• Storage: For extended storage, conserve at −80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Expiry: 12 months from the date of purchase, if it is properly stored.
• Storage Buffer: 0.1M Glicina, 50mM Tris, pH 7.4. No preservatives added.
• Shipping: Dry Ice

Gene Information

• Gene Name: FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]
• Official Symbol: FGFR3
• Synonyms: FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; fibroblast growth factor receptor 3; FGFR-3; fibroblast growth factor receptor 3 variant 4; fibroblast growth factor receptor 3-S; hydroxyaryl-protein kinase; tyrosine kinase JTK4; EC 2.7.10.1
• Gene ID: 2261
• mRNA Refseq: NM_000142
• Protein Refseq: NP_000133
• MIM: 134934
• UniProt ID: P22607