FGFR2

  • Official Full Name

    fibroblast growth factor receptor 2

  • Overview

    The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.

  • Synonyms

    FGFR2;BEK;JWS;CEK3;CFD1;ECT1;KGFR;TK14;TK25;BFR-1;CD332;K-SAM;Crouzon syndrome;Pfeiffer syndrome;fibroblast growth factor receptor 2;OTTHUMP00000020623;Keratinocyte growth factor receptor;OTTHUMP00000020624;OTTHUMP00000020625;OTTHUMP00000020626;OTTHUMP00000020627;OTTHUMP00000020628;OTTHUMP00000020629;OTTHUMP00000020630;OTTHUMP00000020631;bacteria-expressed kinase;OTTHUMP00000020632;FGFR-2;BEK fibroblast growth factor receptor;FGF receptor;EC 2.7.10.1;hydroxyaryl-protein kinase;protein tyrosine kinase, receptor like 14;soluble FGFR4 variant 4;craniofacial dysostosis 1;Jackson-Weiss syndrome;KSAM;CD332 antigen;FLJ98662;EC 2.7.10;OTTHUMP00000020621

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Cynomolgus
  • Rat
  • Mus musculus
  • Xenopus laevis
  • HEK293
  • E.coli
  • Insect Cells
  • Insect Cell
  • Sf21 Insect Cell
  • Mammalian cells
  • Spodoptera Frugiperda
  • Human Cell
  • Sf9 Insect Cell
  • Human
  • Mammalian Cell
  • Human Cells
  • Mamanlian cells
  • Baculovirus-Infected Sf9 Cells
  • HEK293T
  • Sf9 insect cells
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • C-His&hFc
  • Fc
  • His&Fc
  • His&GST
  • GST
  • Non
  • hIgG4
  • his
  • His&Flag
  • Myc&DDK
  • His&Avi
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
FGFR2-621H Active Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Met1-Glu377
FGFR2-705H Active Recombinant Human FGFR2 protein(Met1-Glu377), His&hFc-tagged HEK293 Human C-His&hFc Met1-Glu377
FGFR2-87H Recombinant Human FGFR2, His-tagged E.coli Human His
Fgfr2-501MAF488 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc Met1-Glu263， 483
Fgfr2-501MAF555 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc Met1-Glu263， 483
Fgfr2-501MAF647 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc Met1-Glu263， 483
Fgfr2-501MF Recombinant Mouse Fgfr2 Protein, Fc-tagged, FITC conjugated HEK293 Mouse Fc Met1-Glu263， 483
Fgfr2-502MAF488 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His Met1-Glu263， 253
Fgfr2-502MAF555 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His Met1-Glu263， 253
Fgfr2-502MAF647 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His Met1-Glu263， 253
Fgfr2-502MF Recombinant Mouse Fgfr2 Protein, His-tagged, FITC conjugated HEK293 Mouse His Met1-Glu263， 253
FGFR2-621HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 367
FGFR2-621HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 367
FGFR2-621HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 367
FGFR2-621HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 Human His 367
FGFR2-705HAF488 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human His&Fc 604
FGFR2-705HAF555 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human His&Fc 604
FGFR2-705HAF647 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human His&Fc 604
FGFR2-705HF Recombinant Human FGFR2 Protein, Fc/His-tagged, FITC conjugated HEK293 Human His&Fc 604
FGFR2-7303HAF488 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells Human His&GST 659
FGFR2-7303HAF555 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells Human His&GST 659
FGFR2-7303HAF647 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells Human His&GST 659
FGFR2-7303HF Recombinant Human FGFR2 Protein, His/GST-tagged, FITC conjugated Insect Cells Human His&GST 659
FGFR2-776HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 278
FGFR2-776HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 278
FGFR2-776HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 278
FGFR2-776HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 Human His 278
FGFR2-777HAF488 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 595
FGFR2-777HAF555 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 595
FGFR2-777HAF647 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 595
FGFR2-777HF Recombinant Human FGFR2 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 595
FGFR2-778HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 368
FGFR2-778HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 368
FGFR2-778HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 368
FGFR2-778HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 Human His 368
FGFR2-18H Active Recombinant Human FGFR2 protein, GST-tagged Insect Cell Human GST 285-end a.a.
Fgfr2-368M Active Recombinant Mouse Fgfr2, Fc Chimera Sf21 Insect Cell Mouse Fc
Fgfr2-427M Active Recombinant Mouse Fgfr2, Fc Chimera Mammalian cells Mouse Fc
FGFR2-481H Active Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Human Fc
Fgfr2-542M Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged Spodoptera Frugiperda Mouse Fc 41-308 a.a.
Fgfr2-551M Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged Mammalian cells Mouse Fc 22-378 a.a.
FGFR2-607H Active Recombinant Human FGFR2, His-tagged, Biotinylated Human Cell Human His 22-377 a.a.
FGFR2-608H Active Recombinant Human FGFR2, Fc-tagged, Biotinylated Human Cell Human Fc 22-377 a.a.
Fgfr2-638M Active Recombinant Mouse Fgfr2 Protein, Fc Chimera Mammalian cells Mouse Fc
FGFR2-690H Active Recombinant Human FGFR2, Fc Chimera Mammalian cells Human Fc
FGFR2-691H Active Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Human Fc
FGFR2-821H Active Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell Human GST 285-end
FGFR2-86H Active Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell Human GST 285-end a.a.
FGFR2-2457H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Arg152-Glu377(IIIc)
FGFR2-5755H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Arg152-Glu378(IIIb)
FGFR2-7855H Recombinant Human FGFR2 protein, hFc-tagged HEK293 Human Fc Arg152-Glu378(IIIb)
FGFR2-02H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc-tagged Insect Cell Human Fc
FGFR2-102H Recombinant Human Fibroblast Growth Factor Insect Cell Human Non
FGFR2-1752R Recombinant Rhesus Monkey FGFR2 Protein HEK293 Rhesus macaque Non 22-377 a.a.
FGFR2-1753R Recombinant Rhesus Monkey FGFR2 Protein, hIgG1-tagged HEK293 Rhesus macaque Fc 22-377 a.a.
FGFR2-1754R Recombinant Rhesus Monkey FGFR2 Protein, hIgG4-tagged HEK293 Rhesus macaque hIgG4 22-377 a.a.
FGFR2-28889TH Recombinant Human FGFR2 Human Non Full L.
FGFR2-31452TH Recombinant Human FGFR2, Fc-tagged Human Fc
FGFR2-314H Recombinant Human FGFR2, GST-tagged, Active Sf9 Insect Cell Human GST 285-end a.a.
FGFR2-488H Recombinant Human Fibroblast Growth Factor Receptor 2 Sf21 Insect Cell Human Non
FGFR2-489H Recombinant Human Fibroblast Growth Factor Receptor 2 Mammalian cells Human Non
FGFR2-5002H Recombinant Human Fibroblast Growth Factor Receptor 2 Human Human Non
Fgfr2-501M Recombinant Mouse Fgfr2 protein(Met1-Glu263), hFc-tagged HEK293 Mouse Fc Met1-Glu263
Fgfr2-502M Recombinant Mouse Fgfr2, His-tagged Human Cell Mouse His Met1-Glu263
FGFR2-5418H Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged Insect Cell Human his 403-822 a.a.
FGFR2-595H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera E.coli Human Fc
FGFR2-6871C Recombinant Chicken FGFR2 Mammalian Cell Chicken His
FGFR2-7303H Active Recombinant Human FGFR2 protein, His&GST-tagged Insect Cells Human His&GST Met400-Thr821
FGFR2-777H Recombinant Human FGFR2 protein, hFc-tagged HEK293 Human Fc Arg22-Glu378
FGFR2-778H Recombinant Human FGFR2 Protein, His-tagged HEK293 Human His 1-378 a.a.
FGFR2-791H Recombinant Human FGFR2 Protein, DDK/His-tagged HEK293 Human His&Flag 22-377 a.a.
FGFR2-8029Z Recombinant Zebrafish FGFR2 Mammalian Cell Zebrafish His
FGFR2-82H Recombinant Human FGFR2, MYC/DDK-tagged HEK293 Human Myc&DDK
FGFR2-001MCL Recombinant Mouse FGFR2 cell lysate Human Cell Mouse Non
FGFR2-2578HCL Recombinant Human FGFR2 cell lysate Human Cell Human Non
FGFR2-428HCL Recombinant Human FGFR2 cell lysate Insect Cell Human Non 400-821 a.a.
FGFR2-007H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His It contains Pro 154 - Thr 356 (domain2-3).
FGFR2-008H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Pro154-Leu358
FGFR2-009H Active Recombinant Human FGFR2 protein, Fc-tagged HEK293 Human Fc Pro154-Leu358
FGFR2-050HB Recombinant Human FGFR2 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Arg22-Glu378
FGFR2-055H Recombinant Human FGFR2 protein(IIIb), His-Avi-tagged HEK293 Human His&Avi It contains Arg22-Glu378.
FGFR2-056H Recombinant Human FGFR2 protein(IIIb), His-Avi-tagged HEK293 Human His&Avi It contains Arg22 - Glu289.
FGFR2-057H Recombinant Human FGFR2 protein(IIIb), hFc-tagged HEK293 Human Fc It contains Arg22 - Glu289.
FGFR2-058H Recombinant Human FGFR2 Protein E.coli Human 821
FGFR2-092H Recombinant Human FGFR2 Protein, Arg22-Glu377, C-His-Avi tagged, Biotinylated HEK293 Human His&Avi Arg22-Glu377
FGFR2-093H Recombinant Human FGFR2 Protein, Arg152-Glu378, C-His-Avi tagged, Biotinylated HEK293 Human His&Avi Arg152-Glu378
FGFR2-094H Recombinant Human FGFR2 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Arg152-Glu377
FGFR2-1007M Active Recombinant Mouse FGFR2 protein, His-tagged HEK293 Mouse His Pro39-Leu243
FGFR2-1018C Recombinant Cynomolgus FGFR2 protein, His-tagged HEK293 Cynomolgus His Pro 144 - Thr 346
FGFR2-1230H Recombinant Human FGFR2 Protein (Arg22-Glu377), N-His tagged E.coli Human His Arg22-Glu377
Fgfr2-135M Recombinant Mouse Fgfr2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Fgfr2-135M-B Recombinant Mouse Fgfr2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Fgfr2-1501R Recombinant Rat Fgfr2 Protein, His-tagged E.coli Rat His Arg41-Ala285
FGFR2-151H Recombinant Human FGFR2 Protein, His-tagged Human Cells Human His
FGFR2-186H Recombinant Human FGFR2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
FGFR2-186H-B Recombinant Human FGFR2 Protein Pre-coupled Magnetic Beads HEK293 Human
FGFR2-2055H Recombinant Human FGFR2 Protein, DDK-tagged Insect Cell Human Flag
FGFR2-2149H Active Recombinant Human FGFR2 protein, hFc-tagged HEK293 Human Fc Met1-Glu378
FGFR2-2318H Recombinant Human FGFR2 Protein (22-377), His tagged E.coli Human His 22-377
FGFR2-2334HFL Recombinant Full Length Human FGFR2, Flag-tagged Mamanlian cells Human Flag Full L.
FGFR2-2593H Active Recombinant Human FGFR2 protein Baculovirus-Infected Sf9 Cells Human Non Pro458-Gln778
Fgfr2-3002M Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
FGFR2-33H Recombinant Active Human FGFR2 (M420I) Protein (285-end), N-GST-tagged Sf9 insect cells Human GST 285-end
FGFR2-34H Recombinant Active Human FGFR2 (N549K) Protein (285-end), N-GST-tagged Sf9 insect cells Human GST 285-end
FGFR2-4116H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Arg22-Glu378
FGFR2-4117H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Arg22-Glu377(IIIc)
FGFR2-4128H Recombinant Human FGFR2 Protein Wheat Germ Human Non
FGFR2-412C Recombinant Cynomolgus FGFR2 protein, His-tagged HEK293 Cynomolgus His Pro154-Lys368(IIIb)
FGFR2-4130H Recombinant Human FGFR2 Protein, GST-tagged Wheat Germ Human GST
FGFR2-4891HF Recombinant Full Length Human FGFR2 Protein In Vitro Cell Free System Human Full L. 203 amino acids
FGFR2-4892HF Recombinant Full Length Human FGFR2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 723 amino acids
FGFR2-779H Recombinant Human FGFR2 protein, His-tagged HEK293 Human His Pro 154 - Leu 358
FGFR2-92H Recombinant Active Human FGFR2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human His&Fc Arg22-Glu377
Kit-0341 FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit Non
RFL32092MF Recombinant Full Length Mouse Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (22-821)
RFL34887HF Recombinant Full Length Human Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (22-821)
RFL5970GF Recombinant Full Length Chicken Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length of Mature Protein (24-823)
RFL9320XF Recombinant Full Length Xenopus Laevis Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system Xenopus laevis His Full L. Full Length of Mature Protein (15-813)

    Involved Pathway

    FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway PLCB2,PIK3R5,SIPA1L1,TEK,PLCG1,FGFR1,PLCE1,INS,KITLG,THBS1
    Signaling pathways regulating pluripotency of stem cells NEUROG1,Fzd4,WNT6,MAPK1,FGFR1,FGFR3,WNT3,LIFR,PCGF2,SMARCAD1
    MAPK signaling pathway CACNG6,CACNA1D,PLA2G4C,ZAK,FGF8A,RRAS2,FLNA,FGF1A,TMEM37,PRKCA
    Pathways in cancer LPAR4,LAMC2,BRCA2,CDC42,MAX,FZD3,FZD7,PDGFB,SFPI1,TGFA
    Prostate Cancer INSRR,NFKB1,HSP90AA1,IGF1,RAF1,BCL2,NOXA1,HSP90B1,GRB2,PIK3R2
    Central carbon metabolism in cancer HKDC1,RAF1,PFKM,SIRT6,G6PDX,MAP2K1,GLS,MAPK1,HIF1A,SLC2A2
    PIK-Akt signaling pathway FGF9,SYK,Il2,BAD,IFNA2,IFNAR1,KITLG,FGF11,FGF19,ITGA10
    Endocytosis TGFB1A,VPS26B,HLA-B,H2-Q10,SNX1A,VPS36,HSPA1A,ARF1L,EPN3,MDM2
    Ras signaling pathway GNG8,FGF18,REL,CALML5,PIK3R1,RELA,ELK1,LOC608458,PIK3CA,RAPGEF5

    Protein Function

    FGFR2 has several biochemical functions, for example, ATP binding,fibroblast growth factor binding,fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor binding CXCL13,GLG1,GLG1B,THBS1,KLB,FIBPB,FGFBP3,CEP57,Api5,FIBP
    protein binding DALRD3,ZNF703,CTDP1,POMP,KIAA1267,C16orf45,PLCB1,ZNF426,PAN3,PTPN13
    fibroblast growth factor-activated receptor activity FGFR3,FGFR4,FGFR1A,FGFR1,FGFR1B,FGFRL1
    ATP binding PHKG1A,ATP1A1B,MYO6B,CDK13,GPHN,CHD6,GRK7,DNAJA2L,HSPH1,IP6K3
    heparin binding PLA2G5,ZNF146,CXCL11,VEGFB,TGFBR3,HRG,RPL29,F11,ABP1,LXN
    protein tyrosine kinase activity IGF1RA,HCK,FGFR1,TTK,PTK2B,ZAP70,MAP2K3,PTK6B,TNK2,EPHB2
    protein homodimerization activity DMRT2B,CORO1A,APOC2,CTBP2A,ERN1,KCNK9,BOK,CD8A,CAMK2B,IMPA2

    Interacting Protein

    FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.

    FGF1;ssr;GRB2;FGF2;FGF10

    FGFR2 Related Signal Pathway

    Resources

    Gene Families

    Cytokines

    Research Area

    Cancer Drug Targets
    Cytokine and Growth Factor Receptors on VSMC
    FGF Family
    Other CD Antigen
    Receptor Tyrosine Kinases (RTKs)
    FGF Receptor
    Oncoprotein-Growth Factor Receptors

    References

    • De Vita, F; Di Martino, N; et al. Clinical management of advanced gastric cancer: The role of new molecular drugs. WORLD JOURNAL OF GASTROENTEROLOGY 20:14537-14558(2014).
    • Zhang, Y; Pan, TC; et al. Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression. JOURNAL OF PHARMACOLOGICAL SCIENCES 126:77-83(2014).

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