Recombinant Human FGFR2 protein(IIIb), hFc-tagged

• Cat.No.: FGFR2-057H
• Product Overview: Recombinant Human FGFR2 beta (IIIb) Protein is expressed from mammalian with a hFc tag at the C-terminal. It contains Arg22 - Glu289.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: It contains Arg22 - Glu289.
• Description: Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform.
• Form: Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 56. 6 kDa. Due to glycosylation, the protein migrates to 75-85 KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0. 1 EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
• Official Symbol: FGFR2
• Synonyms: FGF R2b; FGFR2 beta;KGFR;CD332;Keratinocyte growth factor receptor
• Gene ID: 2263
• mRNA Refseq: NM_000141
• Protein Refseq: NP_000132
• MIM: 176943
• UniProt ID: P21802