Epha1
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Official Full Name
EPH receptor A1 -
Overview
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. -
Synonyms
EPHA1;EPH receptor A1;EphA1 , EPHT, EPHT1;ephrin type-A receptor 1;EPH;hEpha1;oncogene EPH;eph tyrosine kinase 1;soluble EPHA1 variant 1;soluble EPHA1 variant 2;tyrosine-protein kinase receptor EPH;erythropoietin-producing hepatoma receptor;er
Recombinant Proteins
- Mouse
- Human
- Chicken
- Sf9 Insect Cell
- HEK293
- Mammalian cells
- Insect Cell
- Wheat Germ
- Mammalian Cell
- E.coli
- Human Cell
- HEK293T
- GST
- Fc
- His
- Non
- His&Flag
- Flag
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Epha1 involved in several pathways and played different roles in them. We selected most pathways Epha1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | LRRC4C,PPP3CC,PAK2,RASGEF1A,PTPRA,MARK3,ROCK2,AP2B1,GDNF,NADL1.1 |
Protein Function
Epha1 has several biochemical functions, for example, ATP binding,protein kinase activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha1 itself. We selected most functions Epha1 had, and list some proteins which have the same functions with Epha1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane-ephrin receptor activity | EPHA4,EFNB3,EFNA3,EPHB1,EPHB2,EPHA10,EPHA5,EFNA4 |
| protein kinase activity | INSRB,BMPR2B,MAPK14B,RPS6KA6,NEK1,PIK3R4,PAK4,TGFBR1,DCLK1A,MAP3K1 |
| ATP binding | SPAST,ABCC10,ABCG1,PIP5K1C,ERBB3B,MYO1G,RPS6KA3,CLK2,CDK20,MYH1B |
| protein kinase binding | SHC1,AP1B1,CAV2,GPRC5B,TCTN2,FGR,STAP1,MAVS,RHOD,TPX2 |
Interacting Protein
Epha1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha1.
npm_alk;saicar;PKM;UBA1;UBE2N;UBE2V1;Map3k1;HSP90AB1
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References
- Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
- Herath, NI; Spanevello, MD; et al. Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis. EUROPEAN JOURNAL OF CANCER 48:753-762(2012).
