Active Recombinant Mouse EPHA1, GST-tagged

• Cat.No.: EPHA1-1400M
• Product Overview: Recombinant mouse EPHA1 (569-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Specification

• Description: EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer.
• Source: Sf9 Cells
• Species: Mouse
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 32 nmol/min/mg
• Molecular Mass: ~71 kDa
• Protein length: 569 aa-end
• Purity: >85%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: Epha1 Eph receptor A1 [ Mus musculus ]
• Official Symbol: EPHA1
• Synonyms: EPHA1; Eph receptor A1; ephrin type-A receptor 1; mEpha1; embryonic stem cell kinase; tyrosine-protein kinase receptor ESK; Eph; Esk; AL033318; 5730453L17Rik
• Gene ID: 13835
• mRNA Refseq: NM_023580
• Protein Refseq: NP_076069
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem
• Function: ATP binding; ephrin receptor activity; kinase activity; nucleotide binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; receptor activity; transferase activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity