Cd14
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Official Full Name
CD14 molecule -
Overview
The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor. -
Synonyms
CD14;monocyte differentiation antigen CD14;OTTHUMP00000159892;OTTHUMP00000223710;OTTHUMP00000223711;OTTHUMP00000224328;myeloid cell-specific leucine-rich glycoprotein
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Rhesus macaque
- Pig
- Cynomolgus
- HEK293
- Mammalian cells
- CHO
- Wheat Germ
- Mammalian Cell
- E.coli
- Insect Cell
- Human Cell
- Human cells
- In Vitro Cell Free System
- HEK293T
- HEK293F
- His
- C-His&hFc
- Fc
- Non
- GST
- His&T7
- His&GST
- Flag
- Myc&DDK
- mFc
- His&Fc&Avi
Involved Pathway
Cd14 involved in several pathways and played different roles in them. We selected most pathways Cd14 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | HLA-DPA1,IL12B,IFNG,RFXAP,ATP6V0A2,CAP18,PPP3R1,SRC,EP300,HLA-DRB1 |
| MAPK signaling pathway | PDGFB,FGFR1,PPP3R1,RAF1A,GRB2,FGF9,TAOK3,MRAS,CACNB4,PDGFRA |
| Salmonella infection | IL-8,PFN2,TLR4BB,MAPK14B,MYD88,MAPK13,NOS2,RILP,WASB,IL1A |
| Toll-like receptor signaling pathway | TLR2-1,FOS,IFNA3,RAC1A,IFNA10,IFNA5,TBK1,PIK3R1,IFNAR2,MAP2K3 |
| Pertussis | C4BPB,CALM2,FOS,C1S,MAPK11,TNF,CALML3,CASP7,ITGB2L,MAPK13 |
| NF-kappa B signaling pathway | XIAP,MAP3K14,CCL4L1,MAP3K7,ZAP70,IKBKG,BCL2L1,TRAF2,TNFSF14,UBE2I |
| Transcriptional misregulation in cancer | NUPR1,ITGAM,ETV6,MMP9,Aff1,MEF2C,BMP2K,ETV7,RUNX1,HIST2H3C2 |
| Pathogenic Escherichia coli infection | ITGB1,TUBA1C,TUBB,CTTN,ROCK2,KRT18,TUBA4A,NCK1,TLR4,FYN |
| Phagosome | ITGAV,ATP6V1BA,ACTB1,TUBA1A,TUBB1,ATP6V0E2,TLR2-1,TUBB5,ATPV0E2,ACTB |
Protein Function
Cd14 has several biochemical functions, for example, lipopolysaccharide binding,lipoteichoic acid binding,opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd14 itself. We selected most functions Cd14 had, and list some proteins which have the same functions with Cd14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipoteichoic acid binding | TREM2,CD6,LBP,TLR2 |
| protein binding | PDK1,TSSK3,ZMYM4,PICK1,TNFSF12,WDTC1,SNRNP40,CHN2,PVRL1,DPYSL2 |
| lipopolysaccharide binding | TLR4,HSPD1,SPON2,SELP,BPIFA2,PSMB4,CD6,TLR2,SCARB1,DROSHA |
| peptidoglycan receptor activity | PGLYRP1,PGLYRP2,PGLYRP3,PGLYRP4 |
Interacting Protein
Cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd14.
FSTL1;IRAK3;DIP2A;TNFRSF1B;GJB2;POLR2J;PPP3R2;ARFGAP3;PHF20L1;b4dt77_human;TAF1;PPP1R12B;BUB1B;SVIL;OASL;TAF9;ARID2
Resources
Research Area
Immune Regulatory Molecules on Endothelial CellsMyeloid Lineage Markers
Inflammatory Mediators
Myeloid Cell
Conventional/Classical Dendritic Cells
Inflammatory/Monocyte-derived Dendritic Cells
Langerhans and Dermal Dendritic Cells
CD Antigen (Dendritic Cell Lineage Markers)
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
Monocyte Markers
MDSC Phenotyping - Negative Markers
Related Services
Related Products
References
- Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
- Troseid, M; Nestvold, TK; et al. Soluble CD14 Is Associated with Markers of Vascular Dysfunction in Bariatric Surgery Patients. METABOLIC SYNDROME AND RELATED DISORDERS 13:119-124(2015).
