BIRC5
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Official Full Name
baculoviral IAP repeat containing 5 -
Overview
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] -
Synonyms
BIRC5;baculoviral IAP repeat containing 5;API4;EPR-1;baculoviral IAP repeat-containing protein 5;apoptosis inhibitor 4;survivin variant 3 alpha;apoptosis inhibitor survivin
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Non
- GST
- Fc&His
- DDK&Myc
- His&TEV
- His&SUMO
- Avi&Fc&His
- Flag
Involved Pathway
BIRC5 involved in several pathways and played different roles in them. We selected most pathways BIRC5 participated on our site, such as Hippo signaling pathway,Hepatitis B,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | NFKBIA,CASP12,IFNA13,MAPK8,RAF1,IFNA6,IL-8,FADD,STAT4,CCNE1 |
| Pathways in cancer | RUNX1,ITGA2,MAPK10,MDM2,MMP9,GNAI2,GNB1,PRKCB,PIK3R1,RASSF1 |
| Hippo signaling pathway | PARD6A,WNT2B,SNAI2,TGFBR1,Fzd4,WNT7A,ID2,FZD3,WNT3A,CCND2 |
| Colorectal cancer | RAC1,MAPK3,MAPK8,Casp3,RAC3,LEF1,RHOA,TGFBR2,FOS,AKT1 |
Protein Function
BIRC5 has several biochemical functions, for example, Ran GTPase binding,chaperone binding,cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC5 itself. We selected most functions BIRC5 had, and list some proteins which have the same functions with BIRC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran GTPase binding | IPO9,IPO5,RANBP10,IPO11,RANBP3,IPO8,NUTF2,XPOT,RANGAP1,KPNB1 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | IGF1RA,BIRC7,TNFSF14,NOL3,BIRC8,TNFAIP8,ARRB1,RPS6KA1,VIL1,AVP |
| cofactor binding | PGAM2,HIF1AN,ME3,ACLYA,C3,DAO,HACL1,TYMS,TKT,ACLY |
| cobalt ion binding | NUDT16,SLC11A2,P2RX2,PML |
| protein homodimerization activity | MGLL,TYMS,MTHFD1L,MGST1,GPD1C,C16orf89,MASP1,EIF2AK1,SP1,HSD17B4 |
| zinc ion binding | NANOS3,MSL2B,MATR3,MICAL2B,KDM5A,TRIM2,ADAMTS7,PML,LMX1BB,RNF144B |
| cysteine-type endopeptidase inhibitor activity | FETUB,BIRC7,CARD16,CTLA2B,CST1,LCN1,Cstb,CST8,CST2,NAIP1 |
| identical protein binding | ROBO2,PUF60,HOOK2,NCAM1,FAM108A1,ALCAMA,APOE,SRPX2,SOD2,LRRK2 |
| chaperone binding | ATP1A3,TBCC,CDC37L1,DNAJA2,SERPINA7,TIMM10,Alb,PRNP,HYOU1,C1orf182 |
Interacting Protein
BIRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC5.
INCENP;CDCA8
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References
- Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
- Chen, J; Pise-Masison, CA; et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. BLOOD 121:2029-2037(2013).
