Recombinant Human baculoviral IAP repeat-containing 5, CaM-tagged

• Cat.No.: BIRC5-376H
• Product Overview: Recombinant human Survivin fused to CaM-tag at N-terminus was expressed in E.coli and purified by conventional chromatography techniques, 33 kDa (294 aa).

Specification

• Cat. No.: BIRC5-376H
• Description: Survivin is a human gene that is part of the inhibitor of apoptosis family (IAP). The Survivin protein functions to inhibit caspase activation therefore leading to negative regulation of apoptosis or programmed cell death.
• Sequences of amino acids: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SHMGAPTLPP AWQPFLKDHR ISTFKNWPFL EGCACTPERM AEAGFIHCPT ENEPDLAQCF FCFKELEGWE PDDDPIEEHK KHSSGCAFLS VKKQFEELTL GEFLKLDRER AKNKIAKETN NKKKEFEETA KKVRRAIEQL AAMD
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: BIRC5 baculoviral IAP repeat-containing 5 [ Homo sapiens ]
• Synonyms: BIRC5; baculoviral IAP repeat-containing 5; API4; EPR-1;apoptosis inhibitor 4; survivin variant 3 alpha; surviving; IAP4; Apoptosis inhibitor survivin; survivin variant 3 alpha
• Gene ID: 332
• mRNA Refseq: NM_001012270
• Protein Refseq: NP_001012270
• MIM: 603352
• UniProt ID: O15392
• Chromosome Location: 17q25
• Pathway: Colorectal cancer; Cell Cycle, Mitotic
• Function: Ran GTPase binding; caspase inhibitor activity; chaperone binding; cofactor binding; enzyme binding;metal ion binding; microtubule binding; peptidase inhibitor activity; protein homodimerization activity; zinc ion binding