ACVR2B
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Official Full Name
activin A receptor, type IIB -
Overview
Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. -
Synonyms
ACVR2B;activin A receptor, type IIB;ACTRIIB;ActR-IIB;HTX4
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- Chicken
- Zebrafish
- Mus musculus
- Xenopus laevis
- HEK293
- CHO
- Sf21 Cells
- E.coli
- Human Cells
- Insect Cells
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- Yeast
- In Vitro Cell Free System
- Fc
- Non
- His
- His&Fc
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
- His&B2M
Involved Pathway
ACVR2B involved in several pathways and played different roles in them. We selected most pathways ACVR2B participated on our site, such as Cytokine-cytokine receptor interaction,TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | SMAD3,ACVR1C,BAMBIA,INHBE,ID2A,RHOAC,RBX1,BMP8A,SP1,RPS6KB1B |
| Signaling pathways regulating pluripotency of stem cells | SKIL,ESX1,WNT1,PCGF6,IGF1R,ESRRB,ACVR1C,STAT3,PCGF1,POU5F1 |
| Cytokine-cytokine receptor interaction | IL11RA2,IFNA13,TP-1,IFNG1-2,TGFBR1B,CCL27,CXCR4A,IL11,IL13RA1,BMPR1BA |
Protein Function
ACVR2B has several biochemical functions, for example, ATP binding,activin binding,contributes_to activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2B itself. We selected most functions ACVR2B had, and list some proteins which have the same functions with ACVR2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine/tyrosine kinase activity | MAP2K2,DYRK3,TNK2,RPS6KA1,TESK2,AURKC,MAP2K1,CLK4,DYRK2,DYRK4 |
| metal ion binding | DNA2,ZNF486,PPP2R3C,THAP4,ZNF498,ZFP629,ZNF436,RNF11A,DMRT1,TSSK5 |
| ATP binding | MCMDC2,BMP2K,RARS2,BLK,CENPE,RUNX2B,HIPK3A,CDK10,MCM5,BUB1B |
| growth factor binding | IGFBP2B,FLT4,RHBDF2,NRP2,HTRA1B,FLT1,OSMR,ACVR1C,GHRHR,RPL37 |
| protein serine/threonine kinase activity | NEK6,CSNK1G2A,LMTK2,CAMK1GB,RPS6KAL,STK32C,HIPK2,CDK11B,SRPK1A,MAP2K7 |
| protein binding | LGALS6,ITGB1BP1,EXOSC1,MTF1,CDK1,CDON,CALM1,PCBD2,CGGBP1,TGFBI |
| activin binding | FST,SMAD7,TGFBR3,FSTL3,FKBP1A,ACVR1,SMURF1,ACVRL1,ENG |
| receptor signaling protein serine/threonine kinase activity | ACVR1L,BMPR1BA,ACVR1C,AMHR2,ALPK2,STK24A,BMPR1AA,BMPR2B,BMPR2A,TGFB2 |
Interacting Protein
ACVR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2B.
MSTN;Mstn;GDF11;FSTL1;INHBA;HSP90AB1;linkable pd173955 analogue;bosutinib;dasatinib
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