Active Recombinant Cynomolgus ACVR2B

• Cat.No.: ACVR2B-193C
• Product Overview: A DNA sequence encoding the cynomolgus ACVR2B (EHH16502.1) (Ser28-Thr143) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Specification

• Species: Cynomolgus
• Source: Human Cells
• Tag: Non
• Protein Length: Ser28-Thr143
• Form: Lyophilized from sterile PBS, pH7.4.
• Bio-activity: Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 0.2-0.6 μg/mL in the presence of 10 ng/mL recombinant Activin A.
• Molecular Mass: The recombinant cynomolgus ACVR2B is a disulfide-linked homodimer. The reduced monomer comprises 123 amino acids and has a calculated molecular mass of 14.1 KDa.The apparent molecular mass of the protein is approximately 34 KDa in SDS-PAGE.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: ACVR2B?activin A receptor, type IIB [?Macaca fascicularis?(crab-eating macaque) ]
• Official Symbol: ACVR2B
• Synonyms: ACVR2B; activin A receptor, type IIB; activin A receptor, type IIB
• Gene ID: 102118668
• mRNA Refseq: XM_005546675
• Protein Refseq: XP_005546732
• Chromosome Location: 2
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway