Recombinant Human Activin A Receptor, Type IIB, His-tagged

• Cat.No.: ACVR2B-938H
• Product Overview: ACVR2B contains C-terminal polyhistidine tag and has a calculated MW of 41 kDa. DTT-reduced protein migrates as 60 kDa polypeptide in SDS-PAGE.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Purity: >97% as determined by SDS-PAGE. All lots are greater than 97% pure.
• Endotoxin: Less than 1.0 EU per 1 μg of the rhACVR2B by the LAL method.
• Storage: Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: ACVR2B activin A receptor, type IIB [ Homo sapiens ]
• Official Symbol: ACVR2B
• Synonyms: ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; MGC116908; EC 2.7.11.30; Activin receptor type-2B; ACTR-IIB; HTX4; OTTHUMP00000161965
• Gene ID: 93
• mRNA Refseq: NM_001106
• Protein Refseq: NP_001097
• MIM: 602730
• UniProt ID: Q13705
• Chromosome Location: 3p22
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP
• Function: ATP binding; activin binding; activin receptor activity, type II; growth factor binding; manganese ion binding; nucleotide binding; protein serine/threonine/tyrosine kinase activity; transferase activity; receptor activity