Recombinant Swine IL21

• Cat.No.: IL21-103S
• Product Overview: Swine IL-21 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

Specification

• Species: Pig
• Source: Yeast
• Tag: Non
• Description: IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
• Form: Lyophilized without carrier protein.
• Molecular Mass: Swine IL-21 has a predicted molecular weight of 15.0 kDa.
• AA Sequence: HKSSFQGQDR LLIRLRQLID TVDQLKNYVH DLDPELLPAP EDVQRHCEQS AFSCFQKVEL KSANTGDNEK IINVLIKQLK RKLPPTNAGR RQKHGLTCPT CDSYEKKPIK EFLERLKSLI QKMIHQHLS
• Purity: >95% as visualized by SDS-PAGE analysis.
• Applications: The Swine IL-21 protein can be used in cell culture, as an IL-21 ELISA Standard, and as a Western Blot Control.
• Storage: Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles.
• Reconstitution: Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.