Active Recombinant Human Il21, HIgG1 Fc-tagged, mutant

• Cat.No.: Il21-001H
• Product Overview: The extracellular domain of human IL-21 (NP_068575.1) (Gln32-Ser162)(Gln145Asp,Gln150Asp) is fused to the N-terminus of the Fc region of mutant human IgG1.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 32-162 a.a.
• Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. Theencoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation,proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells andcytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus,psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoformshave been observed for this gene.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay using N1186 human T cells.
• Molecular Mass: 41KDa (monomer)
• AA Sequence: (Gln32-Ser162)(Gln145Asp,Gln150Asp)
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL21 interleukin 21 [ Homo sapiens ]
• Official Symbol: IL21
• Synonyms: IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21
• Gene ID: 59067
• mRNA Refseq: NM_001207006
• Protein Refseq: NP_001193935
• MIM: 605384
• UniProt ID: Q9HBE4
• Chromosome Location: 4q26-q27
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine activity; cytokine receptor binding; interleukin-2 receptor binding