Active Recombinant Human IL21 Protein, Animal Free

Cat.No. : IL21-31H
Product Overview : Recombinant Human IL21 Protein without tag was expressed in Human cells.
Animal Free and Xeno Free
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Species : Human
Source : Human Cells
Protein Length : 132 aa
Description : IL-21 is a typical family I cytokine with broad pleiotropic actions and is primarily produced by T follicular helper cells, Th17, and natural killer T cells in response to antigenic stimulation. Il-21 generally enhances antigen-specific responses of immune cells. It controls the activation, proliferation, differentiation, cytotoxicity, and survival of various target immune cells. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Bio-activity : The activity was measured by a cell proliferation assay using human N1186 T cells. The ED50 for this effect is about 0.5-5ng/mL.
Molecular Mass : ~15 kDa
Endotoxin : <0.5 EU/ μg
Purity : High Purity, >95% by SDS-PAGE
Stability : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein
Reconstitution : Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Gene Name IL21 interleukin 21 [ Homo sapiens (human) ]
Official Symbol IL21
Synonyms IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21;
Gene ID 59067
mRNA Refseq NM_001207006
Protein Refseq NP_001193935
MIM 605384
UniProt ID Q9HBE4

Not For Human Consumption!

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