Active Recombinant Human IL21 Protein, Animal Free
Cat.No. : | IL21-31H |
Product Overview : | Recombinant Human IL21 Protein without tag was expressed in Human cells. Animal Free and Xeno Free |
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Species : | Human |
Source : | Human Cells |
Protein Length : | 132 aa |
Description : | IL-21 is a typical family I cytokine with broad pleiotropic actions and is primarily produced by T follicular helper cells, Th17, and natural killer T cells in response to antigenic stimulation. Il-21 generally enhances antigen-specific responses of immune cells. It controls the activation, proliferation, differentiation, cytotoxicity, and survival of various target immune cells. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. |
Bio-activity : | The activity was measured by a cell proliferation assay using human N1186 T cells. The ED50 for this effect is about 0.5-5ng/mL. |
Molecular Mass : | ~15 kDa |
Endotoxin : | <0.5 EU/ μg |
Purity : | High Purity, >95% by SDS-PAGE |
Stability : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein |
Reconstitution : | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
Gene Name | IL21 interleukin 21 [ Homo sapiens (human) ] |
Official Symbol | IL21 |
Synonyms | IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21; |
Gene ID | 59067 |
mRNA Refseq | NM_001207006 |
Protein Refseq | NP_001193935 |
MIM | 605384 |
UniProt ID | Q9HBE4 |
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◆ Cell & Tissue Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Not For Human Consumption!
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