Recombinant Rat UBA1 Protein, His (Fc)-Avi-tagged

• Cat.No.: UBA1-6041R
• Product Overview: Recombinant Rat UBA1 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Uba1 ubiquitin-like modifier activating enzyme 1 [ Rattus norvegicus ]
• Official Symbol: UBA1
• Gene ID: 314432
• mRNA Refseq: NM_001014080.1
• Protein Refseq: NP_001014102.1
• UniProt ID: Q5U300

Reviews

07/02/2022

The UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.

07/07/2019

In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

05/13/2017

Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.

Q&As

Are there any clinical trials involving UBA1 as a target?

Some early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.

How can UBA1 be targeted for therapeutic purposes?

Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.

How does UBA1 function in the cell?

UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.

What diseases are associated with UBA1 dysfunction?

UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.

Can UBA1 be a diagnostic marker for ALS?

Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.