Recombinant Rat Hif1a protein, His/S-tagged

• Cat.No.: Hif1a-153R
• Product Overview: Recombinant Rat Hif1a fused with His/S tag was expressed in E. coli.

Specification

• Description: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator(ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
• Source: E. coli
• Species: Rat
• Tag: His&S
• Form: Lyophilized from sterile PBS, pH 7.4
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Store at -70 centigrade. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Rattus norvegicus ]
• Official Symbol: Hif1a
• Synonyms: HIF1A; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; HIF1 alpha; HIF1-alpha; HIF-1 alpha; HIF-1-alpha; hypoxia-inducible factor 1 alpha; hypoxia inducible factor 1, alpha subunit; MOP1
• Gene ID: 29560
• mRNA Refseq: NM_024359
• Protein Refseq: NP_077335
• UniProt ID: O35800
• Chromosome Location: 6q24
• Pathway: Adipogenesis, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Renal cell carcinoma, organism-specific biosystem; Renal cell carcinoma, conserved biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, conserved biosystem
• Function: DNA binding; DNA binding; Hsp90 protein binding; double-stranded DNA binding; histone acetyltransferase binding; histone acetyltransferase binding; histone deacetylase binding; protein binding transcription factor activity; protein complex binding; protein heterodimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; sequence-specific DNA binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding