Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged

• Cat.No.: Tnfrsf10b-6544M
• Product Overview: Purified recombinant protein of mouse full-length tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
• Molecular Mass: 42.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b [ Mus musculus (house mouse) ]
• Official Symbol: Tnfrsf10b
• Synonyms: TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; death receptor 5; KILLER/DR5 TRAIL death-inducing receptor; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
• Gene ID: 21933
• mRNA Refseq: NM_020275
• Protein Refseq: NP_064671
• UniProt ID: Q9QZM4