Recombinant Mouse Sod2, His-tagged

• Cat.No.: Sod2-56M
• Product Overview: Recombinant mouse Sod2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Description: Sod2 also known as superoxide dismutase [Mn], mitochondrial, is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this protein have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
• Form: Liquid, In Phosphate buffered saline (pH7.4) containing 10% glycerol, 1mM DTT
• Molecular Mass: 24.6kDa (221aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSKHSLPDL PYDYGALEPH INAQIMQLHH SKHHAAYVNN LNATEEKYHE ALAKGDVTTQ VALQPALKFN GGGHINHTIF WTNLSPKGGG EPKGELLEAI KRDFGSFEKF KEKLTAVSVG VQGSGWGWLG FNKEQGRLQI AACSNQDPLQ GTTGLIPLLG IDVWEHAYYL QYKNVRPDYL KAIWNVINWE NVTERYTACK K
• Purity: >95% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: Sod2 superoxide dismutase 2, mitochondrial [ Mus musculus ]
• Official Symbol: Sod2
• Synonyms: SOD2; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial; manganese SOD; manganese superoxide dismutase; MnSOD; Sod-2; MGC6144
• Gene ID: 20656
• mRNA Refseq: NM_013671
• Protein Refseq: NP_038699
• Pathway: Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; One carbon metabolism and related pathways, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; Peroxisome, organism-specific biosystem; Peroxisome, conserved biosystem; superoxide radicals degradation, organism-specific biosystem
• Function: DNA binding; identical protein binding; manganese ion binding; metal ion binding; oxidoreductase activity; oxygen binding; superoxide dismutase activity; superoxide dismutase activity; superoxide dismutase activity