Recombinant Mouse SFRP2 protein(Met1-Cys295), His-tagged

• Cat.No.: Sfrp2-862M
• Product Overview: Recombinant Mouse sFRP2 (NP_033170.1) (Met 1-Cys 295) was expressed in HEK293 with a C-terminal polyhistidine tag.

Specification

• Source: HEK293
• Species: Mouse
• Tag: His
• Protein length: Met1-Cys295
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant mouse sFRP2 consists of 282 amino acids after removal of the signal peptide and has a predicted molecular mass of 32.5 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 36 kDa due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Sfrp2 secreted frizzled-related protein 2 [ Mus musculus ]
• Official Symbol: SFRP2
• Synonyms: SFRP2; secreted frizzled-related protein 2; SARP-1; sFRP-2; stromal cell derived factor 5; secreted apoptosis-related protein 1; secreted frizzled-related sequence protein 2; secreted frizzled-related sequence protein 5; Sdf5; AI851596
• Gene ID: 20319
• mRNA Refseq: NM_009144
• Protein Refseq: NP_033170

Reviews

11/13/2021

Fast and affordable protein sequencing; great for identifying unknown proteins.

04/28/2019

Robust protein-protein interaction assays; pivotal for our experiments.

02/20/2018

High-quality protein crystallization; crucial for structural biology studies.

Q&As

How does SFRP2 expression influence stem cell differentiation and regeneration in various tissues?

SFRP2 expression plays a significant role in stem cell differentiation, contributing to tissue regeneration and repair processes.

What role does SFRP2 play in the development and progression of cardiovascular diseases, especially atherosclerosis?

In cardiovascular diseases, SFRP2 plays a role in processes like atherosclerosis, impacting vascular health and disease progression.

What is the impact of SFRP2 on angiogenesis in the context of tumor growth and metastasis?

SFRP2 influences angiogenesis in tumors, affecting tumor growth and the potential for metastasis.

How does SFRP2 interact with Wnt signaling pathways in cancer development, particularly in colorectal and breast cancers?

SFRP2 modulates Wnt signaling in cancers, with specific roles in colorectal and breast cancer development, impacting cell proliferation and migration.

How does SFRP2 modulate bone formation and resorption in osteoporosis and other bone diseases?

SFRP2 is involved in bone metabolism, affecting bone formation and resorption in diseases like osteoporosis.

What are the mechanisms by which SFRP2 contributes to fibrosis in organ systems like the heart and liver?

SFRP2 contributes to fibrosis in organs like the heart and liver, influencing tissue remodeling and function.

How does the alteration of SFRP2 expression affect adipogenesis and metabolic processes in obesity and diabetes?

Alterations in SFRP2 expression affect adipogenesis and metabolic functions, linking it to obesity and diabetes pathologies.