Recombinant Mouse Sema4a protein, Fc-tagged

• Cat.No.: Sema4a-14867M
• Product Overview: Recombinant Mouse Sema4a(Met1-Gln676) fused with Fc region of human IgG1 at N-terminal was expressed in CHO.

Specification

• Source: CHO
• Species: Mouse
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Molecular Mass: 101 Kda
• Protein length: Met1-Gln676
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: ≥98%,by SDS-PAGE under reducing conditions.
• Storage: Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.

Gene Information

• Gene Name: Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [ Mus musculus ]
• Official Symbol: Sema4a
• Synonyms: SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A; sema B; semaphorin-B; semaphorin 4A; SemB; Semab; AI132332
• Gene ID: 20351
• mRNA Refseq: NM_001163489
• Protein Refseq: NP_001156961
• UniProt ID: Q62178
• Chromosome Location: 3; 3 F1
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Other semaphorin interactions, organism-specific biosystem; Semaphorin interactions, organism-specific biosystem
• Function: receptor activity

Reviews

10/29/2022

Swift and accurate service, dependable for data accuracy.

05/22/2022

Invaluable support for insights, a research game-changer.

10/12/2019

Reliable partner in experiments, boosts research efficiency.

Q&As

What is the impact of altered SEMA4A activity on neurodegenerative and autoimmune diseases?

Altered SEMA4A activity is associated with the progression of neurodegenerative and autoimmune conditions.

What potential therapeutic applications arise from targeting SEMA4A in neurological and immune disorders?

Targeting SEMA4A offers potential for treating a range of neurological and immune-mediated disorders.

What role does SEMA4A play in immune regulation?

SEMA4A is involved in immune system regulation, affecting immune cell activation and responses.

What is the primary role of SEMA4A in nervous system development?

SEMA4A, a semaphorin, is crucial for guiding axon development and neural connectivity in the nervous system.

How does SEMA4A contribute to axon guidance?

It plays a key role in directing axonal growth and neuronal network formation.

How does SEMA4A interact with other signaling molecules?

SEMA4A works with various signaling pathways, coordinating developmental and immune processes.

How do genetic variations in SEMA4A affect neural and immune functions?

Genetic changes in SEMA4A can lead to impairments in neural development and immune system functioning.