Recombinant Mouse Pik3r1 Protein, Myc/DDK-tagged

• Cat.No.: Pik3r1-4865M
• Product Overview: Purified recombinant protein of mouse full-length phosphoinositide-3-kinase regulatory subunit 1 (Pik3r1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 83.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [ Mus musculus (house mouse) ]
• Official Symbol: Pik3r1
• Synonyms: PIK3R1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3K; AA414921; p50alpha; p55alpha; p85alpha; C530050K14
• Gene ID: 18708
• mRNA Refseq: NM_001077495
• Protein Refseq: NP_001070963
• UniProt ID: P26450