PIK3R1
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -
Overview
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms. -
Synonyms
PIK3R1;phosphoinositide-3-kinase, regulatory subunit 1 (alpha);phosphatidylinositol 3-kinase regulatory subunit alpha;GRB1;p85;p85 ALPHA;PI3-kinase subunit p85-alpha;PI3K regulatory subunit alpha;ptdIns-3-kinase regulatory subunit alpha;phosphati
Recombinant Proteins
- Human
- Bovine
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Insect Cell
- Leishmania Tarentolae
- Sf9 Insect Cell
- Mammalian Cell
- Insect cells
- HEK293
- HEK293T
- His
- Non
- His&MBP
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pancreatic cancer | ARHGEF6,CDC42,IKBKB,PIK3R5,IKBKG,TGFA,BAD,SMAD4,PIK3CG,TP53 |
| Platelet activation | PRKG2,MAPK11,ITGB3,TBXAS1,PIK3CG,MAPK3,PIK3CB,PLA2G4F,APBB1IP,PRKACG |
| Proteoglycans in cancer | HSPG2,PRKACA,CCND1,MAP2K1,FN1,PPP1CB,WNT2,CAMK2A,TP53,SMAD2 |
| TNF signaling pathway | RPS6KA5,DNM1L,CXCL10,RELA,RPS6KA4,CXCL3,MAPK10,TRAF1,ICAM1,SELE |
| Central carbon metabolism in cancer | GLS2,PFKL,SLC16A3,PFKM,G6PDX,RAF1,PIK3R5,IDH1,PTEN,MAPK3 |
| Epstein-Barr virus infection | TBPL1,NFKB1,HSPB1,RELA,EIF2AK4,HLA-DPB1,CD44,POLR2J,POLR3GL,IL10RA |
| Regulation of Actin Cytoskeleton | PFN1,FGF14,PIK3CA,ARPC5B,RAC3A,SCIN,FN1A,ITGB3B,RAF1B,IQGAP2 |
| Influenza A | IFNA6,TYK2,CPSF4,PRSS3,PRSS2,CXCL10,ACTG1,PIK3CB,IFNA14,HNRNPUL1 |
| PIK-Akt signaling pathway | FGF19,HSP90B1,HRAS,TEK,IFNA13,IFNAR1,GNG5,LPAR5,TCL1B4,MAPK3 |
Protein Function
PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity,ErbB-3 class receptor binding,insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin binding | C2CD2L,IGF1R,INSR,HSPD1,IDE |
| insulin-like growth factor receptor binding | ARRB1,INSL4,GNAS,IGF1,IGF2,INSR,SOCS1,IGF3,INS,Ren1 |
| phosphatidylinositol 3-kinase regulatory subunit binding | PTPN13,FAM83A,XBP1,FAM83B,PIK3AP1,DNM2 |
| transmembrane receptor protein tyrosine kinase adaptor activity | STAP1,TRAT1,GAB2,SHC1,BLNK,FRS2,SH2B2,DOK2,IRS1 |
| insulin receptor substrate binding | GRB2,IGF1RB,PIK3CB,JAK2,PRKCZ,IGF1R,PTPN11,INSRB,INSRR,PRKCD |
| protein phosphatase binding | HSF4,ROS1,RPA3,JUP,DLG4,TRAF3,FGF19,Itga10&Itgb1,NEK2,AP3B1 |
| protein binding | CD6,JOSD1,SNTB1,CALCOCO1,PDE4DIP,SNRNP70,SLC9A3,C15orf57,TP53INP1,NCAPH |
| transcription factor binding | APBB1,PIANP,DR1,HMGA1-RS1,DNMT1,ENPP2,TCF12,TBP,CHCHD2,FOXC1 |
| 1-phosphatidylinositol-3-kinase regulator activity | CCKBR,PIK3R3A,PIK3R2,PIK3R6,PIK3R3B,PIK3R3,PIK3R5 |
Interacting Protein
PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB;CBL
PIK3R1 Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
Intracellular Kinases in the Akt Pathway
PI 3-Kinases (Phosphoinositide 3-Kinases)
Intracellular Signaling Molecules in Angiogenesis
Apical-basal Polarity Effectors
T Follicular Helper (Tfh) Cells
Glioma Biomarkers
PI3K Pathway
Related Services
Related Products
References
- Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
- Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).
