Recombinant Mouse Notch2, Fc-tagged

• Cat.No.: Notch2-436M
• Product Overview: The extracellular domain of mouse Notch2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: 26-494 a.a.
• Description: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
• Form: Lyophilized. Contains PBS.
• Molecular Mass: ~87kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 1mg/ml after reconstitution.
• Publications:
  The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis (2023)

Gene Information

• Gene Name: Notch2 Notch gene homolog 2 (Drosophila) [ Mus musculus ]
• Official Symbol: Notch2
• Synonyms: NOTCH2; Notch gene homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Motch B; notch 2; N2; AI853703
• Gene ID: 18129
• mRNA Refseq: NM_010928
• Protein Refseq: NP_035058
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem
• Function: NF-kappaB binding; calcium ion binding; protein binding; receptor activity