Recombinant Human NOTCH2 protein, His-Avi-tagged

• Cat.No.: NOTCH2-722H
• Product Overview: Human Notch 2 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Leu26-Gln530.

Specification

• Description: Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
• Source: HEK293
• Species: Human
• Tag: His&Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 57 Kda.
• Protein length: Leu26-Gln530
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: NOTCH2
• Official Symbol: NOTCH2
• Synonyms: AGS2; hN2; neurogenic locus notch homolog protein 2; Notch (Drosophila) homolog 2; notch 2Notch homolog 2 (Drosophila); Notch homolog 2; Notch2; Notch-2
• Gene ID: 4853
• mRNA Refseq: NM_001200001.2
• Protein Refseq: NP_001186930.1
• MIM: 600275
• UniProt ID: Q04721