Recombinant Mouse Nae1 Protein, Myc/DDK-tagged
Cat.No. : | Nae1-4281M |
Product Overview : | Purified recombinant protein of mouse full-length NEDD8 activating enzyme E1 subunit 1 (Nae1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Species : | Mouse |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. |
Molecular Mass : | 60.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | Nae1 NEDD8 activating enzyme E1 subunit 1 [ Mus musculus (house mouse) ] |
Official Symbol | Nae1 |
Synonyms | NAE1; NEDD8 activating enzyme E1 subunit 1; NEDD8-activating enzyme E1 regulatory subunit; APP-BP1; amyloid protein-binding protein 1; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa; 59kDa; Appbp1; MGC29435; MGC36437; MGC36630 |
Gene ID | 234664 |
mRNA Refseq | NM_144931 |
Protein Refseq | NP_659180 |
UniProt ID | Q8VBW6 |
◆ Recombinant Proteins | ||
NAE1-724C | Recombinant Cynomolgus NAE1 Protein, His-tagged | +Inquiry |
NAE1-1072HF | Recombinant Full Length Human NAE1 Protein, GST-tagged | +Inquiry |
NAE1-3889R | Recombinant Rat NAE1 Protein | +Inquiry |
NAE1-469C | Recombinant Cynomolgus Monkey NAE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NAE1-10794Z | Recombinant Zebrafish NAE1 | +Inquiry |
◆ Cell & Tissue Lysates | ||
NAE1-3984HCL | Recombinant Human NAE1 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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