NAE1
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Official Full Name
NEDD8 activating enzyme E1 subunit 1 -
Overview
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NAE1;NEDD8 activating enzyme E1 subunit 1;amyloid beta precursor protein binding protein 1 , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein binding protein 1, 59kD , APPBP1;NEDD8-activating enzyme E1 regulato
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- E.coli
- Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- His&GST
- Myc&DDK
Involved Pathway
NAE1 involved in several pathways and played different roles in them. We selected most pathways NAE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | COX6B1,NDUFA1,NDUFS3,RYR3,CALM2,NDUFS7,NDUFC2-KCTD14,GRIN2D,CALM3,mt-Atp8 |
Protein Function
NAE1 has several biochemical functions, for example, contributes_to NEDD8 activating enzyme activity,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAE1 itself. We selected most functions NAE1 had, and list some proteins which have the same functions with NAE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | FAF1,CUL1,ZFP746,MAGEA2,PER3,RANGAP1,CDKN1A,UBE2G2,UBE2N,SUMO1 |
| protein heterodimerization activity | OSTA,CEBPE,PIK3R2,HIST1H2BO,HOMER2,ENO2,CHUK,TAF6,DMRT3,TENM3 |
| protein binding | CSE1L,CHRDL2,FAM86C,DVL1,PIR,NEUROG1,LGALS3,EIF2B2,MAP3K7,METTL15 |
Interacting Protein
NAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAE1.
NEDD8;FBXO11;UBE2M;UIMC1;SREBF2;ALG8;UBQLN4
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