Recombinant Mouse Men1 Protein, Myc/DDK-tagged

• Cat.No.: Men1-4032M
• Product Overview: Purified recombinant protein of mouse full-length multiple endocrine neoplasia 1 (Men1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
• Molecular Mass: 61.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]
• Official Symbol: Men1
• Synonyms: MEN1; multiple endocrine neoplasia 1; menin; AW045611
• Gene ID: 17283
• mRNA Refseq: NM_001168490
• Protein Refseq: NP_001161962
• UniProt ID: O88559