Recombinant Full Length Human MEN1 Protein

• Cat.No.: MEN1-303HF
• Product Overview: Recombinant full length Human Menin with N terminal proprietary tag; Predicted MWt 89.25 kDa including the tag.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• ProteinLength: 575 amino acids
• Description: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.
• Form: Liquid
• Molecular Mass: 89.250kDa
• AA Sequence: MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLS LVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYF PVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELV KKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVA FAVVGACQALGLRDVHLALSEDHAWSWLYLKGSYMRCDRK MEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHL ERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYY RDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNY CREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQ SQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH VGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGE EAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSG PPRKPPGTVAGTARGPEGGSTAQVPAPAASPPPEGPVLTF QSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVS TPSDYTLSFLKRQRKGL
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: MEN1 multiple endocrine neoplasia I [ Homo sapiens ]
• Official Symbol: MEN1
• Synonyms: MEN1; multiple endocrine neoplasia I; menin
• Gene ID: 4221
• mRNA Refseq: NM_000244
• Protein Refseq: NP_000235
• MIM: 613733
• UniProt ID: O00255