MEN1
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Official Full Name
multiple endocrine neoplasia I -
Overview
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] -
Synonyms
MEN1;multiple endocrine neoplasia I;MEAI;SCG2;menin
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- Avi&His
- His
- Non
- Avi&Fc&His
- Flag
- DDK&Myc
- GST
Involved Pathway
MEN1 involved in several pathways and played different roles in them. We selected most pathways MEN1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | FEV,ETV4,IGFBP3,FLT3,MEF2C,TP53,NFKBIZ,HIST3H3,HIST1H3G,MLF1 |
Protein Function
MEN1 has several biochemical functions, for example, R-SMAD binding,Y-form DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEN1 itself. We selected most functions MEN1 had, and list some proteins which have the same functions with MEN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ZGLP1,RFX4,RERE,GATA3,DNMT3B,CDCA5,ARID3A,SHMT2,TRIM24,CREB3L1 |
| transcription regulatory region DNA binding | Arid4b,HMGB2,TBL1XR1,SIX1,SMAD4,TRP53,ZFP161,RELA,RBBP5,KDM1A |
| R-SMAD binding | TRIM33,PARP1,ANKRD1,JUN,PPM1A,FOXH1,FOS,ZEB2,MYOCD,C18orf1 |
| four-way junction DNA binding | HMGB1,HMGB3,RAD51L1,RAD51,RAD51L3,YY1,HMGB2,DMC1 |
| protein N-terminus binding | ARF6,SMARCE1,PEX5,NCOA3,ERCC2,PDLIM5,EXOC4,ATM,ALOX5AP,PPP1CC |
| double-stranded DNA binding | ERCC5,PIN4,TDG,CRY1,MTERF2,RBMS1,NTHL1,TP63,HNRNPDL,XRCC5 |
| protein binding, bridging | SYNM,TJP2,STX1A,FLRT3,FSCN3,TIRAP,FSCN2A,FRMD4A,CAV2,FGB |
| Y-form DNA binding | MSH2,WRN,MSH3,RAD18 |
| protein binding | C12orf43,TTC39B,PRUNE,ZNF524,MED19,TNS4,SSSCA1,HSP90AA1.2,AGGF1,VPS11 |
Interacting Protein
MEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MEN1.
MYH9;Nme1;KMT2A;NFKB1;FANCD2
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References
- Debelenko, LV; Agarwal, S; et al. Menin Immunoreactivity in Secretory Granules of Human Pancreatic Islet Cells. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 22:748-755(2014).
- Iglesias, P; Diez, JJ; et al. MANAGEMENT OF ENDOCRINE DISEASE A clinical update on tumor-induced hypoglycemia. EUROPEAN JOURNAL OF ENDOCRINOLOGY 170:R147-R157(2014).
