Recombinant Mouse Ldlr protein, His & GST-tagged

• Cat.No.: Ldlr-5716M
• Product Overview: Recombinant Mouse Ldlr aa. (Lys263~Arg509 (Accession # P35951)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 60.1kDa
• Protein length: Lys263~Arg509
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.7.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Ldlr low density lipoprotein receptor [ Mus musculus (house mouse) ]
• Official Symbol: Ldlr
• Synonyms: Ldlr; low density lipoprotein receptor; Hlb301; low-density lipoprotein receptor; LDL receptor
• Gene ID: 16835
• mRNA Refseq: NM_001252658.1
• Protein Refseq: NP_001239587.1
• UniProt ID: P35951

Reviews

08/11/2020

The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

10/07/2018

Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

03/04/2017

the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

Q&As

Are there conditions where upregulation of LDLR might be beneficial?

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications?

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction?

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis?

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions?

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.