LDLR
-
Official Full Name
low density lipoprotein receptor -
Overview
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. -
Synonyms
LDLR;FH;FHC;LDLCQ2;low density lipoprotein receptor;low-density lipoprotein receptor;LDL receptor;low-density lipoprotein receptor class A domain-containing protein 3;sLOX-1
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Rat
- Chicken
- Rabbit
- Bovine
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- Human Cell
- Rabbit
- HEK293T
- C-His-Avi
- Human plasma
- E.coli expression system
- His
- His&Avi
- GST
- Non
- Fc
- His&GST
- His&T7
- Strep
- Flag
- His&Fc&Avi
- Myc&DDK
- mFc
Involved Pathway
LDLR involved in several pathways and played different roles in them. We selected most pathways LDLR participated on our site, such as Endocytosis,Ovarian steroidogenesis,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDLR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ovarian steroidogenesis | BMP15,HSD3B2,PRKACB,HSD17B7,IGF1R,HSD3B1,STAR,FSHR,CYP2J6,BMP6 |
| Endocytosis | GRK1B,ARR3A,ERBB3A,CAPZA3,TGFBR1,RAB4A,RHOA,ARF3B,ERBB4A,ACAP1 |
| Aldosterone synthesis and secretion | ADCY7,LIPE,DAGLB,CYP11B2,CREB5,CALM3,CREB3,SLC14A2,KCNK3,CAMK2G |
| Bile secretion | ABCG2,ATP1B4,PRKACG,ABCB1,OSTB,FXYD2,ABCB1A,ADCY7,Adcy4,CYP7A1 |
| Toxoplasmosis | MAP2K3,LAMA5,TGFB1,PIK3R5,LAMA3,LY96,HLA-DRB3,GNAI3,IL12A,BIRC2 |
| Hepatitis C | IFNA16,TRADD,OAS1,GRB2,MAPK8,CLDN18,IFNA7,CLDN20,MAPK11,OAS1A |
Protein Function
LDLR has several biochemical functions, for example, calcium ion binding,clathrin heavy chain binding,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDLR itself. We selected most functions LDLR had, and list some proteins which have the same functions with LDLR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | HLA-DRB1,CCR5,RPSA,PVRL4,MRC1,SLC1A5,HYAL2,CXCR4,SLC10A1,SCARB2 |
| low-density lipoprotein receptor activity | CXCL16,LRP12,OLR1,VLDLR,LRP6 |
| calcium ion binding | TPT1,CAPN11,PITPNM2,HPCA,SYTL4,PLSCR4,C2CD4B,MYL1,PLCH1,CETN4 |
| protease binding | ITGB1,DVL3,MBP,INS2,RYR1,XBP1,TNF,ALPI,THAP5,DPP4 |
| very-low-density lipoprotein particle receptor activity | VLDLR,APOBR |
| protein binding | EIF3C,FDX1L,GAST,ARL8A,ZHX2,EPHA4,CASP7,CFL2,BNIP1,TEKT1 |
| glycoprotein binding | VIM,VLDLR,FBXO6,CD4,FGFR1,CSNK1D,CANX,STX1A,RAB14,FBXO27 |
| receptor activity | GRIN1B,IL18RAP,NLGN3,ABP1,GFRA1A,MED4,PVRL4,GUCY1B3,IL10RA,CD4 |
| clathrin heavy chain binding | CLTA,CLTB,KIAA1199,GPR107,PICALM |
Interacting Protein
LDLR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDLR here. Most of them are supplied by our site. Hope this information will be useful for your research of LDLR.
PCSK9;APOE;APOB;env;FLT1
Resources
Research Area
Lipoprotein Receptors and Associated ProteinsUptake and Transport Molecules on Endothelial Cells
Uptake and Transport Molecules in VSMC
Scavenger Receptors
Related Services
Related Products
References
- Wang, X; Berry, E; et al. MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells. FEBS LETTERS 589:490-496(2015).
- Tavori, H; Rashid, S; et al. On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects. ATHEROSCLEROSIS 238:264-270(2015).
