Recombinant Mouse Gldn Protein, Myc/DDK-tagged

Cat.No. : Gldn-3222M
Product Overview : Purified recombinant protein of mouse full-length gliomedin (Gldn), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Molecular Mass : 59.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name Gldn gliomedin [ Mus musculus (house mouse) ]
Official Symbol Gldn
Synonyms GLDN; gliomedin; collomin; olfactomedin-related protein; cancer related gene - liver 2; cancer-related gene liver 2 protein; Clom; Colm; Crgl2; Crlg2; CRG-L2
Gene ID 235379
mRNA Refseq NM_177350
Protein Refseq NP_796324
UniProt ID Q8BMF8

Not For Human Consumption!

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