GLDN
-
Official Full Name
gliomedin -
Overview
Gliomedin is a member of the collagen superfamily, it is a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin provides a glial cue for the formation of peripheral nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes of ranvier. Eliminating the expression of gliomedin or the addition of a soluble extracellular domain of neurofascin to myelinating cultures abolishes node formation. Gliomedin is expressed in the PNS nodes of ranvier, but not in the CNS nodes of ranvier. Gliomedin also displays high expression in murine and human hepatocellular carcinomas (HCC). Its restricted expression in normal tissues and unique early upregulation during tumor development make it an excellent candidate as a new clinical marker of HCC. -
Synonyms
GLDN;gliomedin;CLOM;COLM;CRGL2;CRG-L2;UNC-112;collomin;colmedin
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Fc
- Myc&DDK
- His&Fc&Avi
- Flag
- Non
Involved Pathway
GLDN involved in several pathways and played different roles in them. We selected most pathways GLDN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GLDN has several biochemical functions, for example, protein binding,protein binding involved in heterotypic cell-cell adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDN itself. We selected most functions GLDN had, and list some proteins which have the same functions with GLDN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPPL3,C16orf79,MAGEA2,PILRB,ZFAND2B,CLIC3,TRPS1,ATRIP,SNRPD1,SFRP5 |
| protein binding involved in heterotypic cell-cell adhesion | NFASC,NRCAM |
Interacting Protein
GLDN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDN here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDN.
Resources
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References
- Kharade, SS; McBride, MJ; et al. Flavobacterium johnsoniae PorV Is Required for Secretion of a Subset of Proteins Targeted to the Type IX Secretion System. JOURNAL OF BACTERIOLOGY 197:147-158(2015).
- Han, HJ; Kursula, P; et al. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:1536-1539(2014).
