Recombinant Mouse Dtx2 Protein, Myc/DDK-tagged

• Cat.No.: Dtx2-2673M
• Product Overview: Purified recombinant protein of mouse full-length deltex 2, E3 ubiquitin ligase (Dtx2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
• Molecular Mass: 67.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dtx2 deltex 2, E3 ubiquitin ligase [ Mus musculus (house mouse) ]
• Official Symbol: Dtx2
• Synonyms: DTX2; deltex 2 homolog (Drosophila); protein deltex-2; mDTX2; Deltex2; AA408415; AU022494; 2610524D08Rik
• Gene ID: 74198
• mRNA Refseq: NM_023742
• Protein Refseq: NP_076231
• UniProt ID: Q8R3P2