Recombinant Mouse Clec4d Protein, Myc/DDK-tagged

• Cat.No.: Clec4d-2186M
• Product Overview: Purified recombinant protein of mouse full-length C-type lectin domain family 4, member d (Clec4d), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in antigen presenting cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 25.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Clec4d C-type lectin domain family 4, member d [ Mus musculus (house mouse) ]
• Official Symbol: Clec4d
• Synonyms: CLEC4D; C-type lectin domain family 4, member d; C-type lectin domain family 4 member D; macrophage C-type lectin; C-type lectin superfamily member 8; C-type lectin, superfamily member 8; macrophage-restricted C-type lectin; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8; mcl; Mpcl; Clecsf8; MGC117678
• Gene ID: 17474
• mRNA Refseq: NM_001163161
• Protein Refseq: NP_001156633
• UniProt ID: Q9Z2H6