Recombinant Mouse Cldn4 Protein, MYC/DDK-tagged

• Cat.No.: Cldn4-901M
• Product Overview: Purified recombinant protein of full-length mouse claudin 4 (Cldn4), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 22.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cldn4 claudin 4 [ Mus musculus (house mouse) ]
• Official Symbol: Cldn4
• Synonyms: Cldn4; claudin 4; Cep-r; Cpetr; Cpetr1; claudin-4; CPE-R; CPE-receptor; clostridium perfringens enterotoxin receptor
• Gene ID: 12740
• mRNA Refseq: NM_009903
• Protein Refseq: NP_034033
• UniProt ID: O35054