CLDN4
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Official Full Name
claudin 4 -
Overview
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. -
Synonyms
CLDN4;claudin 4;CPETR, CPETR1;claudin-4;Clostridium perfringens enterotoxin receptor 1;CPE R;hCPE R;WBSCR8;Williams Beuren syndrome chromosomal region 8 protein;CPE-receptor;Williams-Beuren syndrome chromosomal region 8 protein;CPER;CPE-R;CPE
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Bovine
- Mus musculus
- Chlorocebus Aethiops
- Wheat Germ
- HEK293
- Insect Cells
- Mammalian Cells
- In Vitro Cell Free System
- E.coli
- Non
- His
- Twin Strep
- Strep
- GST
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
CLDN4 involved in several pathways and played different roles in them. We selected most pathways CLDN4 participated on our site, such as Cell adhesion molecules (CAMs),Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | CDH8,INADL,CDH10,CLDN16,CADM2A,CDH2,TESK1,CLDN3,CTNND1,LIMS1 |
| Tight junction | PPP2CB,MYL12.2,YES1,OCLNB,PTENB,CSNK2A2A,PRKCB,MYH9,CLDN23,CTTN |
| Cell-cell junction organization | CLDN20,CLDN16,CADM2,PVRL1A,CDH5,CDH12,CDH7,CDH17,JUP,CDH10A |
| Leukocyte transendothelial migration | PRKCA,PTK2B,ITGAM,MYL12A,PIK3R1,RASSF5,CLDN23,CLDN1,CLDN17,CLDN5 |
| Tight junction interactions | CLDN16,INADL,CLDN7,CLDN23,CLDN20,CLDN3 |
| Cell adhesion molecules (CAMs) | ITGB2,NADL1.2,CTLA4,ITGB1B.2,CLDNF,NLGN4A,CADM1,NCAM2,NFASCA,Ntng2 |
| Hepatitis C | RIPK1,IKBKG,IFN-a,MAPK13,PPP2CB,ARAF,RAF1,NR1H3,IRF3,EIF2AK4 |
| Cell-Cell communication | TESK1,CDH18A,DSCAM,PLEC,F11R.2,CDH24,PVRL2L,DST,PLECA,CLDN7 |
Protein Function
CLDN4 has several biochemical functions, for example, identical protein binding,structural molecule activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN4 itself. We selected most functions CLDN4 had, and list some proteins which have the same functions with CLDN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | CLDN7A,CLDNF,LAMA5,MAP1B,SPRR2A,DSP,PLP1,KRT81,LCE3E,CLDN15LA |
| transmembrane signaling receptor activity | OR103-4,CELSR1,TRPV1,CLEC1B,NRXN2,EGFR,OR4D6,LGR4,CLEC4A,LILRB5 |
| identical protein binding | LYZ,CAD,EWSR1,AXIN1,CLDNG,CLDN10,SIAH1,ERBB3,LEPR,AMELX |
Interacting Protein
CLDN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN4.
TACSTD2
Resources
Research Area
Tight Junction Proteins in VSMCEpithelial Cell Markers and Intracellular Molecules
Claudins
Tight Junctions
Related Services
Related Products
References
- Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
- Hashimi, SM; Yu, S; et al. Immunotoxin-mediated targeting of claudin-4 inhibits the proliferation of cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY 42:1911-1918(2013).
