Recombinant Mouse Bst2 Protein, Myc/DDK-tagged

• Cat.No.: Bst2-1897M
• Product Overview: Purified recombinant protein of mouse full-length bone marrow stromal cell antigen 2 (Bst2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 19.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Bst2 bone marrow stromal cell antigen 2 [ Mus musculus (house mouse) ]
• Official Symbol: Bst2
• Synonyms: BST2; bone marrow stromal cell antigen 2; bone marrow stromal antigen 2; HM1.24 antigen; DAMP-1 protein homolog; GREG; Bst-2; C87040; DAMP-1; 2310015I10Rik
• Gene ID: 69550
• mRNA Refseq: NM_198095
• Protein Refseq: NP_932763
• UniProt ID: Q8R2Q8