BST2
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Official Full Name
bone marrow stromal cell antigen 2 -
Overview
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. -
Synonyms
BST2;bone marrow stromal cell antigen 2;bone marrow stromal antigen 2;CD317;tetherin;BST-2;NPC-A-7;HM1.24 antigen
Recombinant Proteins
- Human
- Cynomolgus
- Rat
- Rhesus macaque
- Mouse
- Human Cell
- N-His
- HEK293
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- Fc
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BST2 involved in several pathways and played different roles in them. We selected most pathways BST2 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with BST2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | PAQR3B,NRG2A,FGFR1B,SPTA1,TAB1,IFIT11,DAB2IPB,CASPB,LAMTOR2,TRIM26 |
| Immune System | KIF26A,MAP3K8,CTSD,ART1,CYBA,ASB7,KLRB1B,LGALS9,OSBPL1A,DYNC1I2 |
| Interferon Signaling | USP18,EIF4G2A,FCGR1B,SAMHD1,TRIM3,IFI6,ISG20,TRIM45,TRIM8,IFIT8 |
| Interferon alpha/beta signaling | SAMHD1,IRF2,GBP2,IFI27,IFIT3,IFITM2,IFI6,IFI35,IFITM3,IRF4 |
Protein Function
BST2 has several biochemical functions, for example, metalloendopeptidase inhibitor activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BST2 itself. We selected most functions BST2 had, and list some proteins which have the same functions with BST2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | USH2A,DYNAP,PACS1,RTN4RL1,ENTPD3,TNPO3,FAM32A,ASGR1,SCRT1,FCHSD2 |
| protein homodimerization activity | NKX2-5,DMRTC1B,TFAP4,DMRTC2,VPS4B,CADM2,TBX18,CLIC6,HNF4A,BMP2B |
| signal transducer activity | GNAI2A,HTR1AA,EEF1D,PLCL1,CCR1L1,S100A9,PPP1R12A,GHSRA,TAAR12E,CHRM5B |
| metalloendopeptidase inhibitor activity | WFIKKN2,SPOCK1,TIMP2,TIMP4,TIMP3,WFIKKN1,TIMP2B,SPOCK3,TIMP1,COL4A3 |
| poly(A) RNA binding | ZFP326,SRPR,RRP9,RRP1,SNIP1,KHDRBS1,RPL10L,MRPS35,MRM1,HNRNPH3 |
Interacting Protein
BST2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BST2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BST2.
vpu;Ap1m1;vpu;HARS2;HAGH;yycF;Bmpr1a;TMPO;CAPZA2;Ptpn23;Chmp4b
Resources
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References
- Fang, KH; Kao, HK; et al. Overexpression of BST2 Is Associated With Nodal Metastasis and Poorer Prognosis in Oral Cavity Cancer. LARYNGOSCOPE 124:E354-E360(2014).
- Pham, TNQ; Lukhele, S; et al. HIV Nef and Vpu protect HIV-infected CD4+T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2. RETROVIROLOGY 11:-(2014).
