Recombinant Mouse Aspa Protein, MYC/DDK-tagged

• Cat.No.: Aspa-531M
• Product Overview: Purified recombinant protein of full-length mouse aspartoacylase (Aspa), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 35.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Aspa aspartoacylase [ Mus musculus (house mouse) ]
• Official Symbol: Aspa
• Synonyms: Aspa; aspartoacylase; Acy2; nur7; Acy-2; aspartoacylase; aminoacylase-2; aspartoacylase (aminoacylase) 2; EC 3.5.1.15
• Gene ID: 11484
• mRNA Refseq: NM_023113
• Protein Refseq: NP_075602
• UniProt ID: Q8R3P0