Recombinant Human WEE1 Protein (M291-K575), Tag Free

Cat.No. : WEE1-0059H
Product Overview : Recombinant Human (G)-Wee1(M291-K575) Protein was expressed in Insect cell.
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Species : Human
Source : Insect Cells
Tag : Non
Protein Length : M291-K575
Description : Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Form : Liquid
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name WEE1 WEE1 homolog (S. pombe) [ Homo sapiens (human) ]
Official Symbol WEE1
Synonyms WEE1; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase; WEE1+ homolog; WEE1A; WEE1hu; FLJ16446; DKFZp686I18166;
Gene ID 7465
mRNA Refseq NM_001143976
Protein Refseq NP_001137448
MIM 193525
UniProt ID P30291

Not For Human Consumption!

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