Recombinant Human V-set and immunoglobulin domain containing 4 Protein, His&Flag tagged

• Cat.No.: VSIG4-212H
• Product Overview: Recombinant human VSIG4 protein (Q9Y279-1) (Arg 20-Pro 283) with both His, Flag tag at the C-terminus was expressed in HEK293.

Specification

• Description: This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
• Source: HEK293
• Species: Human
• Tag: C-His&Flag
• Protein length: 20-283aa
• Molecular Mass: 31.9 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: VSIG4 V-set and immunoglobulin domain containing 4 [ Homo sapiens (human) ]
• Official Symbol: VSIG4
• Synonyms: VSIG4; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; Z39IG; protein Z39Ig; Ig superfamily protein; complement receptor of the immunoglobulin superfamily; CRIg
• Gene ID: 11326
• mRNA Refseq: NM_001100431
• Protein Refseq: NP_001093901
• MIM: 300353
• UniProt ID: Q9Y279

Reviews

11/08/2021

Stable performance, excellent performance in a variety of experiments.

10/01/2021

No side effects, high safety.

03/13/2021

It has good antigenicity and can induce target immune response.

Q&As

What is the relationship of VSIG4 to other genes or proteins?

VSIG4 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How can the disease be treated by regulating the levels of VSIG4?

There are no drugs that directly regulate VSIG4 levels, but they can affect VSIG4 expression and function by modulating the immune system.

How to detect and analyze mutations in VSIG4?

Mutations in VSIG4 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What is the specific role of VSIG4 in tumor immunity?

VSIG4 plays an important role in tumor immunity, which can inhibit the activation and function of T cells and NK cells, thereby promoting tumor growth and metastasis.

How to study the regulatory mechanism of VSIG4?

Studying the regulatory mechanism of VSIG4 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the mutation types of VSIG4?

The types of mutations in VSIG4 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.