Recombinant Human ULBP1 Protein (26-215), C-Fc/Avi-tagged

• Cat.No.: ULBP1-12H
• Product Overview: Human ULBP1, also known as RAET1I, N2DL-1, NKG2DL1, UL16 binding protein 1. GenBank Accession No. NM_025218, a.a. 26-215, fused at the C-terminus of the Fc portion of Human IgG1, with C-terminal Avi-tag™, expressed in a HEK293 cell expression system. MW = 51 kDa. This protein runs at a higher molecular weight due to glycosylation.

Specification

• Description: The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Fc&Avi
• Form: Aqueous buffer solution.
• Molecular Mass: 51 kDa
• Protein length: 26-215
• Purity: ≥90%
• Usage: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
• Storage: At least 6 months at –80 centigrade.
• Storage Buffer: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
• Shipping: At -80 centigrade.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: ULBP1 UL16 binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: ULBP1
• Synonyms: ULBP1; UL16 binding protein 1; N2DL-1; RAET1I; NKG2DL1; UL16-binding protein 1; NKG2D ligand 1; alcan-beta; retinoic acid early transcript 1I
• Gene ID: 80329
• mRNA Refseq: NM_025218
• Protein Refseq: NP_079494
• MIM: 605697
• UniProt ID: Q9BZM6