Recombinant Human TYMS protein, His-tagged

Description :	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Source :	Insect cells
Species :	Human
Tag :	His
Form :	50mM Tris-HCl pH8.0, 150mM NaCl, 10% glycerol.
Molecular Mass :	36 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Storage :	Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration :	>50 ug/mL as determined by microplate BCA method

Gene Name	TYMS thymidylate synthetase [ Homo sapiens ]
Official Symbol	TYMS
Synonyms	TYMS; thymidylate synthetase; TS; thymidylate synthase; HsT422; TMS; Tsase; TSase; HST422; MGC88736;
Gene ID	7298
mRNA Refseq	NM_001071
Protein Refseq	NP_001062
MIM	188350
UniProt ID	P04818
Chromosome Location	18p11.31-p11.21
Pathway	Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem;
Function	cofactor binding; folic acid binding; methyltransferase activity; nucleotide binding; thymidylate synthase activity; thymidylate synthase activity; transferase activity;