Recombinant Human TNK1 Protein (Full Length), N-His tagged

• Cat.No.: TNK1-11H
• Product Overview: Purified recombinant protein of Human tyrosine kinase, non-receptor, 1 (TNK1), full length, with N-terminal His tag, expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Full Length
• Description: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 71.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Applications: Cell culture: For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: > 50 μg/mL as determined by microplate BCA method
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea

Gene Information

• Gene Name: TNK1 tyrosine kinase non receptor 1 [ Homo sapiens (human) ]
• Official Symbol: TNK1
• Synonyms: TNK1; tyrosine kinase non receptor 1; KOS1; non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1; EC 2.7.10.2
• Gene ID: 8711
• mRNA Refseq: NM_003985
• Protein Refseq: NP_003976
• MIM: 608076
• UniProt ID: Q13470