Active Recombinant Human TNK1 Protein (1-510aa), N-GST tagged

• Cat.No.: TNK1-702H
• Product Overview: Active recombinant human TNK1 protein (1-510) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-510 a.a.
• Description: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Bio-activity: The specific activity of TNK1 was determined to be 14 nmol/min/mg as per activity assay protocol.
• Molecular Mass: ~85 kDa
• Purity: > 75%
• Stability: One year at -70 centigrade from date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Shipping: Shipped on dry ice

Gene Information

• Gene Name: TNK1 tyrosine kinase non receptor 1 [ Homo sapiens (human) ]
• Official Symbol: TNK1
• Synonyms: TNK1; tyrosine kinase non receptor 1; KOS1; non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1; EC 2.7.10.2
• Gene ID: 8711
• mRNA Refseq: NM_003985
• Protein Refseq: NP_003976
• MIM: 608076
• UniProt ID: Q13470